Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  1
• Reference
  J:73128 Boackle SA, et al., Cr2, a candidate gene in the murine sle1c lupus susceptibility locus, encodes a dysfunctional protein. Immunity. 2001 Nov;15(5):775-85
• ID
  MGI:2446516

Genes

Gene
Cr2
Sle1c

Notes

• Experiment
  The NZM2410 interval contains the Sle1 QTLs and originated from an (NZB x NZW) cross. In order to construct congenic strains of mice which contain selected Sle loci, NZM2410 were backcrossed to C57BL/6J mice six successive times, screening progeny withPCR or SSR markers for specific genomic intervals. One such locus Sle1c resided in an interval of mouse Chromosome 1 that contained Cr2 which is a possible candidate for Sle1c. There were at least 16 nucleotide sequence differences between NZW and C57BL/6J at the Cr2 locus. The authors provided evidence suggesting that Cr2 is the disease susceptibility gene corresponding to the Sle1c QTL.