Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  18
• Reference
  J:82118 Qin Y, et al., A major locus on mouse chromosome 18 controls XX sex reversal in Odd Sex (Ods) mice. Hum Mol Genet. 2003 Mar 1;12(5):509-15
• ID
  MGI:2653284

Genes

Gene	Assay Type
Odsm1	visible phenotype
D18Mit189	PCR amplified length variant
D18Mit210	PCR amplified length variant
Smad7	reported elsewhere
Smad2	reported elsewhere
Smad4	reported elsewhere

Notes

• Experiment
  F2 mice from a fertile (AXFVB) F1 XX Ods/F1 female mated to (AXFVB) F1 XY Ods/F1 male were informative in identifying a region of mouse Chromosome 18 that modifies Ods expression. The locus representing this region is identified as Odsm1 and is within aregion defined by markers D18Mit189 and D18Mit210. Authors suggest Madh2 , Madh4 and Madh7 as potential candidates for Odsm1. Homozygosity for FVB/N-derived alleles at Odsm1 appears to favor sex reversal whereas homozygosity for A/J-derived alleles appears to inhibit sex reversal.