Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  2
• Reference
  J:77487 Ruivenkamp CA, et al., Ptprj is a candidate for the mouse colon-cancer susceptibility locus Scc1 and is frequently deleted in human cancers. Nat Genet. 2002 Jul;31(3):295-300
• ID
  MGI:2654057

Genes

Gene	Allele	Assay Type
Ptprj	Ptprj^Scc1-r	resistance/susceptibility
Ndufs3		overlapping clones, sequence analysis
Mtch2		overlapping clones, sequence analysis
Fnbp4		overlapping clones, sequence analysis
Nup160		overlapping clones, sequence analysis

Notes

• Experiment
  Mouse strains STS/A and BALB/c carry alleles of Scc1 conferring cancer susceptibility and resistance. Haplotypes recombinant in the region containing Scc1 were tested for cancer susceptibility. Data from the recombinants narrowed Scc1 to the region between the STS derived markers D2Nki31 and D2Nki39. A physical map of this interval was constructed and one gene Ptprj was identified. 16 different single nucleotide substitutions resulting in 5 amino acid changes were observed in this gene between the STS and BALB/c mice. Loss of heterozygosity of the human PTPRJ gene was also observed in several human carcinomas. These suggest that variations in the Ptprj gene is responsible for the Scc1 phenotype. Additional functional assays will be required to confirm this. Several other genes were identified outside the Scc1 interval. The order of genes around this region was determined to be: centromere - 3'-Ptprj-5' - 5'-Gtl1-13-3' - Fnbp4 - Mtch2 - Ndufs3 - telomere.