Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  6
• Reference
  J:82715 Lipoldova M, et al., Susceptibility to Leishmania major infection in mice: multiple loci and heterogeneity of immunopathological phenotypes. Genes Immun. 2000 Feb;1(3):200-6
• ID
  MGI:2656516

Genes

Gene	Assay Type
Lmr4	resistance/susceptibility
Lmr4a	resistance/susceptibility
Lmr4c	resistance/susceptibility
D6Mit122
Lmr4b	resistance/susceptibility
D6Mit10

Notes

• Experiment
  This study reports on the dissection of genetic and functional aspects of susceptibility to Leishmania major infecton using two contrasting inbred strains BALB/cHeA (susceptible) and STS/A (resistant) and a resistant Recombinant Congenic (RC) Strain, CcS-5/Dem, which carries a random set of 12.5% of genes from the strain STS and 87.5% genes from the susceptible strain BALB/c. The CcS5/Dem strain was highly resistant despite its overall genetic similarity to BALB/c. The genetic dissection of resistance of the RC strain CcS5 was presented in this study.
  
  The F2 hybrids between (BALB/c CcS5) were genotyped with microsatellite markers covering the 12 STS derived segments on eight chromosomes. Linkage analysis of different parameters of the disease revealed five novel loci, Lmr3 - Lmr7, affecting the response to the infection, each associated with a different combination of pathological symptoms and immunological reactions.
  
  02.25.2016 Curator Note: We have retained the broader QTL identified in this study as Lmr4. We have also assigned official nomenclature to each of the independent traits that map with significance within the broader Lmr4 locus creating Lmr4a, Lmr4b, and Lmr4c.
  
  Lmr4, leishmaniasis resistance 4, mapped to Chr 6 peaking with markers D6Mit122 and D6Mit10. Within the Lmr4 QTL:
  Lmr4a a main effects QTL, linked with D6Mit122 was associated with larger skin lesions post infection, corrected p=0.0017, The BALB/c allele was associated with the larger lesions. [Table 2].
  Lmr4b, mapping to D6Mit10 was identified in interaction with Lmr5f (D10Mit25), corrected p=0.011. [Table 3].
  Lmr4c, mapping to D6Mit122 was also identified in interaction with Lmr5f (D10Mit25), corrected p=0.064. Homozygous BALB/c alleles at Lmr4b, Lmr4c and at Lmr5f were associated with increased IFN gamma levels. [Table 3].
  
  Igk, immunoglobulin kappa chain complex; Tnfrsfr1, tumor necrosis factor receptor superfamily, member 1a; and Ltbr, lymphotoxin B receptor are suggested as a potential candidate genes for Lmr4. [Table 4].