Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• ID
  MGI:2656540

Genes

Gene	Assay Type
D1Mit65	SSLP
Cia15	visible phenotype
Cia20	visible phenotype
D1Mit76	SSLP
D1Mit48	SSLP

Notes

• Experiment
  135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.
  
  Two novel loci associated with CIA mapped to mouse Chromosome 1.
  
  Cia20 (mCia14) mapped to peak marker D1Mit65 at approximately 8 cM. Cia20 is linked to IFN-gamma production (LOD=2.9).
  
  Cia15 (mCia15) mapped to an interval spanning 33cM - 54cM, flanked by markers D1Mit76 and D1Mit48, and is linked to soluble CD44 production (LOD=2.8).