Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• ID
  MGI:2656560

Genes

Gene	Assay Type
Cia13	visible phenotype
Cia14	visible phenotype
D5Mit105	SSLP
D5Mit304	SSLP
D5Mit278	SSLP
D5Mit31	SSLP
Pgia18	visible phenotype
D5Mit227	SSLP

Notes

• Experiment
  135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant. A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.
  
  Pgia18, novel locus associated with PGIA, mapped to an interval spanning 0 cM - 9 cM on mouse Chromosome 5 flanked by the centromere and marker D5Mit227.. Pgia18 is linked to arthritis score (LOD=4.0), arthritis onset (LOD=3.6) and susceptibility (LOD=2.7).
  
  Two novel loci associated with CIA mapped to mouse Chromosome 5.
  
  Cia13 (mCia10) mapped to an interval spanning 26cM - 41cM, flanked by markers D5Mit105 and D5Mit304. Cia13 is linked to arthritis severity (LOD=4.1), susceptibility (LOD=3.0) and total arthritis score (5.0).
  
  Cia14 (mCia11) mapped to an interval spanning 61cM - 78cM, flanked by markers D5Mit278 and D5Mit31. Cia14 is linked to arthritis severity (LOD=6.1), onset (LOD=4.2), susceptibility (LOD=4.0) and total arthritis score (LOD=7.8).