Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• ID
  MGI:2656568

Genes

Gene	Assay Type
Cia16	visible phenotype
Pgia22	visible phenotype
D8Mit242	SSLP
D8Mit320	SSLP

Notes

• Experiment
  135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.
  
  A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.
  
  Pgia22, a novel locus associated with PGIA, mapped to an interval spanning 47cM - 59cM on mouse Chromosome 8 flanked by markers D8Mit242 and D8Mit320. Pgia22 is linked to IL-1 production (LOD=3.1)
  
  A novel locus associated with CIA, Cia16, maps to mouse Chromosome 8 at approximately 28 cM with peak marker D8Mit46. Cia16 is linked to soluble CD44 production (LOD=3.3).
  
  (*Authors list D8Mit46 as the marker in close linkage with Cia16, but this MIT marker has been re-named D9Mit1000.)