Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  19
• Reference
  J:82018 Adarichev VA, et al., Combined autoimmune models of arthritis reveal shared and independent qualitative (binary) and quantitative trait loci. J Immunol. 2003 Mar 1;170(5):2283-92
• ID
  MGI:2656614

Genes

Gene	Assay Type
Pgia23	visible phenotype
D19Mit30	SSLP
Cia12	visible phenotype
D19Mit59	PCR amplified length variant
D19Mit93	PCR amplified length variant

Notes

• Experiment
  135 SSLP markers were screened in a set of 939 (BALB/cCrl x DBA/1J)F2 intercross animals to identify QTLs associated with collagen-induced arthritis (CIA) and proteoglycan-induced arthritis (PGIA). Parental strain BALB/cCrl is CIA-resistant and PGIA-susceptible while parental strain DBA/1J is CIA-susceptible and PGIA-resistant.
  
  A major locus was identified on mouse Chromosome 17 in linkage to both CIA (LOD=21) and PGIA (LOD=6). This locus, Pgia17, has been previously identified and maps to proximal Chromosome 17.
  
  Pgia23, a novel locus associated with PGIA, mapped to approximately 20 cM on mouse Chromosome 19 with peak marker D19Mit30. Pgia23 is linked to IL-6 production (LOD=3.1).
  
  A novel locus associated with CIA, Cia12, maps to 1 cM on mouse Chromosome 19 flanked by markers D19Mit59 and D19Mit93. Cia12 is linked to total arthritis score (LOD=3.1).