Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:82236 Cook R, et al., Identification of a single QTL, Mptp1, for susceptibility to MPTP-induced substantia nigra pars compacta neuron loss in mice. Brain Res Mol Brain Res. 2003 Feb 20;110(2):279-88
• ID
  MGI:2656759

Genes

Gene	Assay Type
Mptp1	resistance/susceptibility
D1Mit113	PCR amplified length variant
D1Mit293	PCR amplified length variant

Notes

• Experiment
  58 animals from either a (C57BL/6J x Swiss Webster)F2 intercross or a (C57BL/6J x Swiss Webster)F1 x Swiss Webster backcross were screened for 61 polymorphic markers (average resolution = 30 cM) to detect QTLs associated with MPTP-induced neuron loss. Parental strain C57BL/6J is susceptible to MPTP-induced neuron loss of the substantia nigra while parental strain Swiss Webster is resistant. A QTL named Mptp1 on mouse Chromosome 1 was identified with LOD=4.5 and a QTL range of 93.3 cM - 109.6 cM between D1Mit113 and D1Mit293. Surprisingly, C57BL/6J-derived alleles confer resistance to MPTP-induced neuron loss with a dominant mode of inheritance. Homozygosity for Swiss Webster-derived alleles at Mptp1 is associated with increased neuron loss.