Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  2
• Reference
  J:81606 Masinde GL, et al., Quantitative trait loci (QTL) for lean body mass and body length in MRL/MPJ and SJL/J F(2) mice. Funct Integr Genomics. 2002 Aug;2(3):98-104
• ID
  MGI:2656820

Genes

Gene	Assay Type
Lbm1	visible phenotype
D2Mit367	PCR amplified length variant
Lbm2	visible phenotype
D2Mit44	PCR amplified length variant
Lgth1	visible phenotype
Lgth2	visible phenotype
D2Mit285	PCR amplified length variant

Notes

• Experiment
  Genome scan was performed on 633 (MRL/MpJ x SJL/J)F2 animals to identify QTLs associated with lean body mass and body length. Parental strain MRL/MpJ exhibits a higher amount of lean body mass compared to parental strain SJL/J. Several lean body mass (Lbm) and body length (Lgth) QTLs were mapped. MRL/MpJ-derived alleles confer increased lean body mass at all Lbm loci. Lbm1, Lbm2, Lgth1, and Lgth2 map to mouse Chromosome 2 at 26.3 cM (LOD=3.6) , 50.3 cM (LOD=9.0), 50.3 cM (LOD=10.8), and 72.1 cM (LOD=9.7), respectively. (Lbm2 and Lgth1 overlap.) Lbm1 is inherited additively while Lbm2 is inherited dominantly. Lgth3 maps to 30.6 cM on mouse Chromosome 4 with LOD=2.7 at D4Mit178. Lbm3 and Lbm4 map to mouse Chromosome 6 at 17.5 cM (LOD=4.7) and 49.2 cM (LOD=4.7), respectively. Lbm3 exhibits a dominant mode of inheritance and Lbm4 exhibits an additive mode of inheritance. Lbm5 maps to 8 cM on mouse Chromosome 7 with LOD=2.9 at D7Mit22 and exhibits an additive mode of inheritance. Lbm6 and Lgth4 both map to 7.7 cM (LOD=7.5 and LOD=4.7, respectively), and Lbm7 and Lgth5 both map to 31.7 cM (LOD=4.7 and LOD=2.3, respectively) on mouse Chromosome 9. Lbm6 and Lbm7 exhibit dominant inheritance. Lgth6 maps to 43.7 cM on mouse Chromosome 11 with LOD=4.8 at D11Mit36. Lbm8and Lgth8 both map to 23 cM (LOD=4.2 and LOD=2.3, respectively), and Lbm9 and Lgth7 both map to 2.2 cM (LOD=3.9 and LOD=2.7, respectively) on mouse Chromosome 13. Lbm8 and Lbm9 exhibit additive inheritance. Lbm10 maps to 40.4 cM on mouse Chromosome 14with LOD=4.7 at D14Mit32 and exhibits additive inheritance.