Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:82261 Iraqi FA, et al., Chromosomal regions controlling resistance to gastro-intestinal nematode infections in mice. Mamm Genome. 2003 Mar;14(3):184-91
• ID
  MGI:2660603

Genes

Gene	Assay Type
Hbnr1	resistance/susceptibility
D1Mit211	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on an (SWR x CBA)F2 intercross population to identify loci affecting resistance/susceptibility to infection by the nematode Heligmosomoides polygyrus. Animals were orally infected with 125 larvae of H. polygyrus weekly for a period of 6 weeks. Parental strain SWR is resistant to nematode infection whereas CBA is susceptible. Loci with significant linkage were detected on mouse Chromosomes 1 and 17. Hpnr1 maps to 15 cM on mouse Chromosome 1 with LOD=12.52 for total worm count at D1Mit211. SWR-derived alleles appear to confer dominantly inherited resistance to nematode infection at Hpnr1. Hpnr2 and Hpnr3 map to 15.1 cM and 50.6 cM on mouse Chromosome 17, respectively. Hpnr2 is linked to total worm count with a LOD score of 4.28 at D17Mit29. SWR-derived alleles confer resistance to nematode infection at Hpnr2. Hpnr3 is linked to fecal egg count with a LOD score of 3.95 between D17Mit93 and D17Mit123. SWR-derived alleles confer dominantly inherited susceptibility to nematode infection at Hpnr3.