Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:81605 Masinde GL, et al., Quantitative trait loci that harbor genes regulating muscle size in (MRL/MPJ x SJL/J) F(2) mice. Funct Integr Genomics. 2002 Aug;2(3):120-5
• ID
  MGI:2660625

Genes

Gene	Assay Type
Musz1	visible phenotype
D7Mit22	PCR amplified length variant

Notes

• Experiment
  Genome scan was performed on 633 animals from an (MRL/MpJ x SJL/J)F2 cross to identify loci influencing muscle size and body length. 119 markers were screened at an average resolution of 15 cM. Five QTLs showing significant linkage to muscle size (P<0.005) were mapped. Musz1 maps to 5.5 cM on mouse Chromosome 7, Musz2 and Musz3 map to 21.9 cM and 40.4 cM on mouse Chromosome 14, respectively, Musz4 maps to 13.1 cM on mouse Chromosome 15, and Musz5 maps to 41.5 cM on mouse Chromosome 17. These 5 QTLs explain 19.2% of the phenotypic variance. A sixth suggestive QTL mapped to 7.7 cM on mouse Chromosome 9 and appears to influence body length as well as muscle size.
  
  Previously identified body length QTLs were detected in this study: Lgth1 (LOD=6.21 at D2Mit182) and Lgth2 (LOD=8.7 at D2Mit304) on mouse Chromosome 2, Lgth4 (LOD=4.1 at D9Mit90) on mouse Chromosome 9, and Lgth6 (LOD=2.7 at D11Mit36) on mouse Chromosome 11.
  
  A novel body length QTL, Lgth9, mapped to 6.6 cM on mouse Chromosome 17 with LOD=4.1 at D17Mit175.