Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:83227 Trezena AG, et al., Co-localization of quantitative trait loci regulating resistance to Salmonella typhimurium infection and specific antibody production phenotypes. Microbes Infect. 2002 Nov;4(14):1409-15
• ID
  MGI:2661159

Genes

Gene	Assay Type
Ssta1	resistance/susceptibility
D1Mit303	PCR amplified length variant
Ssta2	resistance/susceptibility
D1Mit356	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on the highest and lowest antibody titer animals from an (HIII x LIII)F2 cross to identify QTLs associated with susceptibility to infection by Salmonella typhimurium. The animals were intraperitonally injected with S.typhi antigens and measured for antibody titers. HIII is a high antibody responder strain whereas LIII is a low antibody responder strain. Four loci were identified with significant linkage to susceptibility to Salmonella infection. Ssta1 and Ssta2 mapped to mouse Chromosome 1 at 34.8 cM (D1Mit303) and 95.8 cM (D1Mit356), respectively. Ssta1 is linked to anti-flagellar antibody production and Ssta2 is linked to both anti-flagellar antibody production and autosomal antigen activity. Ssta3 maps to 35 cM on mouse Chromosome 6 in linkage to D6Mit128 and D6Mit6. Ssta3 is associated with anti-flagellar antibody production. Ssta4 maps to 37 cM on mouse Chromosome 11 at D11Mit5 and is also associated with anti-flagellar antibody production.