Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  13
• Reference
  J:83220 Jackson AU, et al., Genetic polymorphisms in mouse genes regulating age-sensitive and age-stable T cell subsets. Genes Immun. 2003 Jan;4(1):30-9
• ID
  MGI:2661402

Genes

Gene	Assay Type
Pcd4ts2	visible phenotype
D13Mit64	PCR amplified length variant
Cd4ts6	visible phenotype
D13Mit57	PCR amplified length variant

Notes

• Experiment
  Interval mapping was performed on a (BALB/c x C57BL/6)F1 x (C3H x DBA/2)F1 cross to identify QTLs affecting the level of T cell subsets in virgin and mated animals at 8 and 18 months of age. A QTL associated with P-glycoprotein positive CD4 T cell subsetlevels, Pcd4ts2, mapped to 30 cM (D13Mit64) on mouse Chromosome 13 and a QTL associated with CD4 T cell subset levels, Cd4ts6, mapped to 9 cM (D13Mit57) on mouse Chromosome 13 with statistical significance of P<0.05. Pcd4ts2 is associated with P-glycoprotein positive CD4 T cell levels in 8 month old mated mice. Cd4ts6 is associated with CD4 T cell levels in 18 month old virgin mice.