Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  15
• Reference
  J:80619 Hillebrandt S, et al., Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology. 2002 Dec;123(6):2041-51
• ID
  MGI:2661488

Genes

Gene	Assay Type
Hfib1	visible phenotype
D15Mit122	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 358 animals from an (A/J x BALB/cJ)F2 cross with an average marker resolution of 20 cM to identify QTLs influencing hepatic fibrosis. Parental strain BALB/cJ is susceptible to hepatic fibrosis whereas parental strain A/Jis resistant. A significant locus at 21.5 cM on mouse Chromosome 15 was identified and named Hfib1. Hfib1 gives a peak LOD score of 4.0 at D15Mit122. BALB/cJ-derived alleles confer recessively inherited susceptibility to hepatic fibrosis at Hfib1.