Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:83233 Prows DR, et al., Genetic susceptibility to nickel-induced acute lung injury. Chemosphere. 2003 Jun;51(10):1139-48
• ID
  MGI:2662355

Genes

Gene	Assay Type
Aliq4	resistance/susceptibility
D6Mit183	PCR amplified length variant
Sftpb	reported elsewhere

Notes

• Experiment
  307 (C57BL/6J x A/J) x A/J backcross animals were screened for 77 microsatellite markers to identify QTLs affecting nickel-induced acute lung injury. Parental strain A/J is sensitive to nickel-induced acute lung injury (as measured by mean survival time (MST) after aerosol exposure to nickel sulfate) whereas C57BL/6J is resistant. Significant linkage was detected at 26.5 cM on mouse Chromosome 6 with a LOD score of 3.0 at D6Mit183. This locus is named Aliq4, acute lung injury QTL 4. Suggestive QTLs mapped to 25.7 cM on mouse Chromosome 1 with a LOD score of 2.5 at D1Mit213 and to 11 cM - 22 cM on mouse Chromosome 12 with a LOD score of 2.3 at D12Mit185 and D12Mit112. Microarray analysis was used to complement the QTL analysis by identifying genes differentially expressed between C57BL/6J and A/J as potential candidate genes. Sftpb is one such gene and maps near Aliq4 at 31 cM.