Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  5
• Reference
  J:81197 Johnson KR, et al., Ahl2, a second locus affecting age-related hearing loss in mice. Genomics. 2002 Nov;80(5):461-4
• ID
  MGI:2662459

Genes

Gene	Assay Type
Ahl7	visible phenotype
D5Mit309	PCR amplified length variant
D5Mit235	PCR amplified length variant
Ahl2	visible phenotype

Notes

• Experiment
  110 (NOD/LtJ x C57BL/6J)F1 x NOD/LtJ backcross animals were typed for 90 microsatellite markers to identify loci linked to age-related hearing loss. Parental strain NOD/LtJ exhibits profound hearing loss at 6 months of age as measured by auditory brainstem response (ABR) threshold. A QTL mapped to 44 cM on mouse Chromosome 5 with a LOD score of 5.5 at D5Mit309. NOD/LtJ-derived alleles confer recessively inherited hearing loss at this locus, named Ahl2.
  
  The authors also analyzed a (CAST/Ei x NOD/LtJ)F1 x NOD/LtJ backcross population and mapped a significant QTL with LOD=4 to 42 cM at D5Mit235. This most likely represents the same locus, Ahl2. Again, NOD/LtJ-derived alleles confer recessively inherited hearing loss at this locus.
  
  10.13.2015 Curators Note: Because Ahl2 was originally mapped here using the (NOD/LtJ x C57BL/6J)F1 x NOD/LtJ backcross, which differs from the second cross, we consider the second cross a separate mapping experiment and have named that QTL Ahl7.