Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:83649 Zygourakis CC, et al., Quantitative trait loci modulate ventricular size in the mouse brain. J Comp Neurol. 2003 Jun 30;461(3):362-9
• ID
  MGI:2664096

Genes

Gene	Assay Type
Vent1	visible phenotype
D8Mit94	PCR amplified length variant
D8Mit189	PCR amplified length variant

Notes

• Experiment
  228 animals from 26 AXB and BXA recombinant inbred (RI) strains were analyzed at 669 genetic loci to identify QTLs linked to cerebral ventricular size. Parental strain A/J exhibits a small ventricle compared to parental strain C57BL/6J.
  
  A QTL named Vent1 mapped to an interval spanning 13 cM - 18 cM on mouse Chromosome 8. Vent1 reaches a peak LOD score of 4.1 between D8Mit94 and D8Mit189. C57BL/6J-derived alleles confer increased ventricular size at Vent1.
  
  A highly significant (LRS=45.1) interaction was detected between D4Mit237 (13.3 cM) on mouse Chromosome 4 and D7Mit178 (0.5 cM) on mouse Chromosome 7. These loci were named Vent2 and Vent3, respectively. C57BL/6J-derived alleles at both Vent2 and Vent3 confers increased ventricle size. A possible candidate gene for Vent2 is Tgfbr1.