Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:83608 Angel JM, et al., Identification of Novel Genetic Loci Contributing to 12-O-Tetradecanoylphorbol-13-acetate Skin Tumor Promotion Susceptibility in DBA/2 and C57BL/6 Mice. Cancer Res. 2003 Jun 1;63(11):2747-51
• ID
  MGI:2664121

Genes

Gene	Assay Type
Psl3	resistance/susceptibility
D1Mit511	PCR amplified length variant

Notes

• Experiment
  310 female (C57BL/6 x BXD-27/Ty)F2 animals were analyzed for QTLs associated with sensitivity to TPA-induced skin tumors. Parental strain C57BL/6 is resistant to TPA-induced skin tumors whereas parental strain BXD-27/Ty is susceptible. The strongest linkage was detected at 87 cM on mouse Chromosome 2 near D2Mit286 and was named Psl2 (promotion susceptibility QTL 2). DBA/2-derived alleles confer dominant susceptibility to TPA-induced tumors at this locus. A locus with an additive effect, Psl3 mapped to 111 cM on mouse Chromosome 1 near D1Mit511. C57BL/6-derived alleles confer susceptibility to TPA-induced tumors at this locus. Lastly, Psl4 mapped to 47 cM on mouse Chromosome 19 near D19Mit38. C57BL/6-derived alleles confer dominant resistance to TPA-induced tumors at Psl4.