Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:81203 Brich J, et al., Genetic modulation of tau phosphorylation in the mouse. J Neurosci. 2003 Jan 1;23(1):187-92
• ID
  MGI:2664868

Genes

Gene	Assay Type
Tauph	visible phenotype
D16Mit224	PCR amplified length variant
App	reported elsewhere
Sod1	reported elsewhere

Notes

• Experiment
  Genome scan was performed on a population of (BALB/cByJ-Dab1^tm2Cpr x C57BL/6J)F2 animals to identify QTLs associated with tau phosphorylation. The Dab1^tm2Cpr mutation is viable on a BALB/cByJ background but not on a 129/Sv x C57BL/6J mixed background. A significant QTL associated with tau phosphorylation, Tauph, mapped to 60 cM on mouse Chromosome 16 with a LOD score of 3.2 at D16Mit224. BALB/cByJ-derived alleles confer increased tau phosphorlyation in a dominant manner at this locus. Possible candidate genes near Tauph are Sod1 and App. Suggestive QTLs mapped to mouse Chromosomes 1 (D1Mit365), 12 (D12Mit014), and 17 (D17Mit142).