Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:78169 Furuse T, et al., QTL analyses of spontaneous activity by using mouse strains from Mishima battery. Mamm Genome. 2002 Aug;13(8):411-5
• ID
  MGI:2669263

Genes

Gene	Assay Type
Loco1	visible phenotype
D3Mit128	PCR amplified length variant
D3Tk1	PCR amplified length variant

Notes

• Experiment
  Two separate backcross populations were analyzed for loci associated with spontaneous activity. Parental strains NJL/Ms and KJR/Ms are hyperactive whereas parental strain BLG2/Ms is hypoactive. 93 polymorphic markers at an average spacing of 20 cM were screened in (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms and (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross populations.
  
  A locus reached peak significance in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population at D3Mit128 (83.5 cM, LOD=4.8) on mouse Chromosome 3 and was named Loco1. KJR/Ms-derived alleles appear to confer increased activity at this locus.
  
  A second locus mapped to mouse Chromosome 17 at D17Mit168 (23 cM, LOD=2.2) in the (KJR/Ms x BLG2/Ms)F1 x BLG2/Ms population and was named Loco2. This locus interacts epistatically with Loco1. KJR/Ms-derived alleles confer increased activity at Loco2 only when KJR/Ms alleles are also present at Loco1.
  
  Linkage analysis of the (NJL/Ms x BLG2/Ms)F1 x BLG2/Ms backcross population did not yield any QTLs.