Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:82664 Roubertoux PL, et al., Analysis of quantitative trait Loci for behavioral laterality in mice. Genetics. 2003 Mar;163(3):1023-30
• ID
  MGI:2669472

Genes

Gene	Assay Type
Ltry	visible phenotype
D4Mit205a	PCR amplified length variant
D4Mit12	PCR amplified length variant
D4Mit139	PCR amplified length variant
D4Mit87	PCR amplified length variant
D4Mit178	PCR amplified length variant
D4Mit80	PCR amplified length variant
D4Mit297	PCR amplified length variant
D4Mit15	PCR amplified length variant
D4Mit9	PCR amplified length variant
D4Mit16	PCR amplified length variant
Lepr	reported elsewhere

Notes

• Experiment
  Genome scan was performed on 283 (C57BL/6ByJ x NZB/BlNJ)F2 animals using 67 microsatellite markers to identify QTLs associated with right-left paw laterality. Parental strain NZB/BlNJ is more ambidextrous in both the forepaw and hindpaw compared to parental strain C57BL/6ByJ.
  
  A significant locus was identified on mouse Chromosome 4 and named Ltry (laterality). This locus is linked to forepaw laterality at 48 cM (LOD=5.6 at D4Mit205a), and is linked to hindpaw laterality at 49.7 cM (LOD=7.2 at D4Mit12).Ltry is also linked to plasma lutenizing hormone concentration (PLHC) at 48.8 cM with LOD=4.4. The QTL interval of Ltry spans approximately 30 cM - 63 cM. Low forepaw and hindpaw laterality values and high PLHC values are associated with the NZB/BlNJ-derived allele. A possible candidate gene for Ltry is the leptin receptor, Lepr. This gene maps to 46.7 cM on mouse Chromosome 4 and has been implicated in the gonadal steroid cycle.