Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:83350 Sundberg JP, et al., Major locus on mouse chromosome 17 and minor locus on chromosome 9 are linked with alopecia areata in C3H/HeJ mice. J Invest Dermatol. 2003 May;120(5):771-5
• ID
  MGI:2670453

Genes

Gene	Assay Type
Alaa1	visible phenotype
D17Mit134	PCR amplified length variant
H2	reported elsewhere
Tnf	reported elsewhere
Lta	reported elsewhere
Ltb	reported elsewhere

Notes

• Experiment
  352 (C3H/HeJ x C57BL/6J)F2 female animals were screened for 211 microsatellite markers to identify QTLs associated with alopecia areata. Up to 20% of female animals from parental strain C3H/HeJ develop alopecia areata after 5 months of age (males developalopecia later) whereas animals from parental strain C57BL/6J are resistant to the condition.
  
  Significant linkage was detected at 16.9 cM on mouse Chromosome 17 with a peak LOD=10.9 at D17Mit134. This locus is named Alaa1 (alopecia areata 1) and spans aninterval from 12 cM - 20 cM. Possible candidate genes mapping to this region are the H2 locus, Tnf, Lta, and Ltb. C3H.SW-H2b/SnJ congenic animals carrying a resistant H2b allele on a susceptible C3H/HeJ background do not develop alopecia giving evidence of the role of H2 in this phenotype. The Alaa1 region corresponds to region associated with alopecia areata in human gene studies.
  
  A suggestive locus mapped to 20 cM on mouse Chromosome 9 with LOD=2.0 at D9Mit206.