Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:86189 Lundberg P, et al., A locus on mouse chromosome 6 that determines resistance to herpes simplex virus also influences reactivation, while an unlinked locus augments resistance of female mice. J Virol. 2003 Nov;77(21):11661-73
• ID
  MGI:2682424

Genes

Gene	Assay Type
Hrl	resistance/susceptibility
Tnfrsf1a	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 275 129S6/SvEvTac x (129S6/SvEvTac x C57BL/6J)F1 backcross animals to map the herpes resistance locus, Hrl. Parental strain 129S6/SvEvTac is susceptible to infection by HSV-1 whereas parental strain C57BL/6J is resistant. Hrl is tightly linked to Tnfrsf1a on mouse Chromosome 6 (60 cM) and may be a prime candidate gene. Animals homozygous for a mutation in Tnfrsf1a exhibit a high mortality rate when challenged with HSV-1 (LD50=320 PFU) compared to wild type C57BL/6J (LD50>10⁵ PFU). Klra8, a gene responsible for resistance to infection by murine cytomegalovirus, maps near Hrl at approximately 63 cM but was excluded as a candidate gene since it does not show linkage to HVS-1-induced mortality. C57BL/6J-derived alleles confer dominant resistance to HSV-1 infection at Hrl.
  
  A locus referred to as Sml (sex modifier locus) was also identified in the 129S6/SvEvTac x (129S6/SvEvTac x C57BL/6J)F1 backcross with no map position given by the authors. Sml affects HSV-1 resistance in female animals.