Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  3
• Reference
  J:76108 Mathews CE, et al., Genetic control of neutrophil superoxide production in diabetes-resistant ALR/Lt mice. Free Radic Biol Med. 2002 Apr 15;32(8):744-51
• ID
  MGI:2683699

Genes

Gene	Assay Type
Susp	visible phenotype
D3Mit241	PCR amplified length variant
Etfdh	reported elsewhere
Rap1a	reported elsewhere
Il12a	reported elsewhere
Il6ra	reported elsewhere
Arnt	reported elsewhere

Notes

• Experiment
  44 animals from an (ALS/Lt x ALR/Lt)F1 x ALS/Lt backcross were genotyped at 68 polymorphic loci to identify QTLs associated with resistance to oxidative stress. Parental strain ALS/Lt is susceptible to oxidative stress where as parental strain ALR/Lt is resistant to oxidative stress and exhibits a suppressed neutrophil superoxide burst.
  
  A locus named Susp (suppressor of superoxide production) mapped to approximately 33 cM on mouse Chromosome 3 with P < 0.0001 at D3Mit241. The QTL interval of Susp spans25 cM - 45 cM. ALR/Lt-derived alleles confer reduced superoxide production at Susp in a codominant manner. Possible candidate genes mapping to the Susp interval are Etfdh, Rap1a, Il12a, Il6ra, and Arnt.