Mapping Data

Experiment

• Experiment
  TEXT-Physical Mapping
• Chromosome
  10
• Reference
  J:86905 Noben-Trauth K, et al., Association of cadherin 23 with polygenic inheritance and genetic modification of sensorineural hearing loss. Nat Genet. 2003 Sep;35(1):21-3
• ID
  MGI:2683728

Genes

Gene
D10Mit160
D10Ntra57
D10Ntra42
D10Ntra39
D10Ntra46
D10Ntra48
Cdh23
Cdh23
Cdh23
D10Mit48

Notes

• Experiment
  Cdh23 was mapped within the congenic interval containing DNA segments D10Mit160 and D10Mit48. Occupying the same congenic region are markers mdfw and ahl. The authors found polymorphisms within this region . The positions of the polymorphisms were orders as D10Ntra57 - D10Ntra42 - D10Ntra39 - Cdh23<10497 del11> - Cdh23 ^INS7+117A - Cdh23^753A - Cdh23^685A - D10Ntr46 - D10Ntra48. A significant association of a polymorphism (Cdh23^753A) within exon 7 of Cdh23 was suggested to cause the ahl phenotype.