Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  10
• Reference
  J:86760 Wright FA, et al., Genome scan for blood pressure loci in mice. Hypertension. 1999 Oct;34(4 Pt 1):625-30
• ID
  MGI:2684028

Genes

Gene	Assay Type
Sysbp1	visible phenotype
D10Mit20	PCR amplified length variant
D10Mit123	PCR amplified length variant
D10Mit117	PCR amplified length variant

Notes

• Experiment
  Three different mouse crosses were used to map QTLs associated with systolic blood pressure. Genome scan was performed using 91 - 95 markers at an average spacing of 16 cM. The mouse populations used were a (BPH/2J x BPL/1J)F2 intercross (n=247), an (M. spretus x BPL/1J)F1 x BPL/1J backcross (n=92), and an (M. spretus x BPL/1J)F1 x M. spretus backcross (n=84). Parental strain BPL/1J exhibits low blood pressure whereas parental strains M. spretus and BPH/2J exhibit high blood pressure.
  
  Significant linkage to systolic blood pressure, Sysbp1, mapped to 35 cM (D10Mit20) on mouse Chromosome 10 with LOD=4.4 between D10Mit123 (4 cM) and D10Mit117 (48 cM). This locus was identified in the (BPH/2J x BPL/1J)F2 intercross. BPL/1J-derived alleles confer additivelyinheriteddecrease in systolic blood pressure at Sysbp1.
  
  A second locus exhibiting significant linkage to systolic blood pressure, Sysbp2, mapped to 16 cM (D13Mit198) on mouse Chromosome 13 with LOD=3.3 between D13Mit16 (10 cM) and D13Mit186 (36 cM). This locus was identified in the (M. spretus x BPL/1J)F1 x M. spretus backcross. BPL/1J-derived alleles confer increased blood pressure at Sysbp2. A possible candidate gene mapping to this region is Agtr1a.
  
  Suggestive linkage to systolic blood pressure mapped to 16 cMon mouse Chromosome 8 (LOD=3.2 at D8Mit64), 20 cM and 52.5 cM on mouse Chromosome 2 (LOD=3.1 between D2Mit149 and D2Mit92; LOD=3.2 at D2Mit92, respectively), 74 cM on mouse Chromosome 6 (LOD=2.5 at D6Mit15), and to 16 cM on mouse Chromosome 18 (LOD=2.3 at D18Mit60).
  
  Suggestive linkage to pulse rate mapped to 14 cM on mouse Chromosome 3 (LOD=4.2 between D3Mit60 and D3Mit22), 75 cM on mouse Chromosome 13 (LOD=2.8 at D13Mit78), 19.5 cM on mouse Chromosome 14 (LOD=3.5 at D14Mit19), 66 cM on mouse Chromosome9 (LOD=2.8 between D9Mit81 and D9Mit52), 44 cM on mouse Chromosome 18 (LOD=2.5 at D18Mit103), and to 62 cM on mouse Chromosome X (LOD=2.6 at DXMit35).