Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  10
• Reference
  J:86703 Idel S, et al., A20, a regulator of NFkappaB, maps to an atherosclerosis locus and differs between parental sensitive C57BL/6J and resistant FVB/N strains. Proc Natl Acad Sci U S A. 2003 Nov 25;100(24):14235-40
• ID
  MGI:2684205

Genes

Gene	Assay Type
Ath11	resistance/susceptibility
Tnfaip3	reported elsewhere

Notes

• Experiment
  Tnfaip3 was identified and investigated as a candidate gene for the QTL Ath11 on mouse Chromosome 10. No differences in Tnfaip3 expression level was found between parental strains FVB/N and C57BL/6J. However, sequence analysis revealed a Glu627Ala amino acid substitution between C57BL/6J and FVB/N, respectively. This functional polymorphism is thought to result in increased Nfkb inhibition in FVB/N compared to C57BL/6J.