Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  1
• Reference
  J:87289 Cook SA, et al., Two spontaneous mutant alleles, rb and rb-2J, of the Epha4 gene on mouse Chromosome 1. Mouse Mutant Resources Web Site, The Jackson Laboratory, Bar Harbor, Maine. MGI Direct Data Submission. 2004;
• ID
  MGI:2687087

Genes

Gene	Assay Type	Description
Epha4	visible phenotype	rb and rb-2J
D1Mit77
D1Mit181
D1Mit7
D1Mit46
D1Mit333
D1Mit132
D1Mit216
D1Mit44

Notes

• Experiment
  The rb-2J allele is a remutation at the rb locus. The authors mated a C3Sn.B6-rb/rb female with a C57BL/6J +/rb-2J male which produced 4 visibly affected mice from 2 litters of 11 total progeny. The map position of rb was mapped to mouse Chromosome1 using microsatellite markers and 75 F2 mutants from a B6-rb-2J x CAST/Ei intercross. The results are given in centimorgans +/- standard error: D1Mit77-2.01 +/- 1.14-[D1Mit181, D1Mit7, D1Mit46, D1Mit333, D1Mit132, rb-2J]___ 0.67 +/- 0.66-[D1Mit216, D1Mit44]. Targeted and gene-trap mutations of the Epha4 gene cause a hopping gait
  in mice providing the authors with evidence that rb and rb-2J are mutations within the Epha4 gene.