Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:86889 Woo DD, et al., Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003 Nov 11;15(3):236-42
• ID
  MGI:3026896

Genes

Gene	Assay Type
Abbp2	visible phenotype
D4Mit111	PCR amplified length variant
D4Mit166	PCR amplified length variant

Notes

• Experiment
  Genome scan using 110 microsatellite markers at an average spacing of 15 cM was performed on a population of (A/J x C5BL/6)F2 intercross animals to identify QTLs associated with blood pressure. Parental strain A/J exhibits low blood pressure whereas parental strain C57BL/6 exhibits high blood pressure. A selective genotyping strategy was implemented using F2 animals exhibiting blood pressure greater than 1 standard deviation from the mean.
  
  Abbp1 mapped to mouse Chromosome 1 between 23 cM and 48 cM withpeak linkage to blood pressure between D1Mit303 and D1Mit217 (LOD=6.8) C57BL/6-derived alleles confer increased blood pressure with an additive mode of inheritance at Abbp1. Abbp1 colocalizes with a previously mapped QTL named Bpq1. Human chromosome 2q33-34 is syntenic to the Abbp1 locus.
  
  Abbp2 mapped to mouse Chromosome 4 with peak linkage to blood pressure between D4Mit111 and D4Mit166 (LOD=9.8). C57BL/6-derived alleles confer increased blood pressure at Abbp2 with a recessive mode of inheritance. Abbp2 colocalizes with a previously mapped QTL named Bpq3. Human chromosome 9q31-32 is syntenic to the Abbp2 locus.
  
  Abbp3 (a female-specific QTL) mapped to mouse Chromosome 7 with peak linkage to blood pressure between D7Mit228 and D7Mit37 (LOD=5.4). C57BL/6-derived alleles confer increased blood pressure in female animals at Abbp3 with an additive mode of inheritance. Abbp3 was shown to interact with a locus at D17Mit80 (LRS=38.8).
  
  Abbp4 mapped to mouse Chromosome 11 with peak linkage to blood pressure between D11Mit212 and D11Mit124. C57BL/6-derived alleles confer increased blood pressure at Abbp4 with a recessive mode of inheritance. Candidate genes mapping near Abbp4 include Slc4a1, Car10, Cacnb1, Psa, and Igfbp4. Human chromosome 17q12-23 is syntenic to the Abbp4 locus.