Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:86889 Woo DD, et al., Mapping blood pressure loci in (A/J x B6)F2 mice. Physiol Genomics. 2003 Nov 11;15(3):236-42
• ID
  MGI:3026898

Genes

Gene	Assay Type
Abbp4	visible phenotype
D11Mit212	PCR amplified length variant
D11Mit124	PCR amplified length variant
Slc4a1	reported elsewhere
Cacnb1	reported elsewhere
Npepps	reported elsewhere
Igfbp4	reported elsewhere
Car10	reported elsewhere

Notes

• Experiment
  Genome scan using 110 microsatellite markers at an average spacing of 15 cM was performed on a population of (A/J x C5BL/6)F2 intercross animals to identify QTLs associated with blood pressure. Parental strain A/J exhibits low blood pressure whereas parental strain C57BL/6 exhibits high blood pressure. A selective genotyping strategy was implemented using F2 animals exhibiting blood pressure greater than 1 standard deviation from the mean.
  
  Abbp1 mapped to mouse Chromosome 1 between 23 cM and 48 cM withpeak linkage to blood pressure between D1Mit303 and D1Mit217 (LOD=6.8) C57BL/6-derived alleles confer increased blood pressure with an additive mode of inheritance at Abbp1. Abbp1 colocalizes with a previously mapped QTL named Bpq1. Human chromosome 2q33-34 is syntenic to the Abbp1 locus.
  
  Abbp2 mapped to mouse Chromosome 4 with peak linkage to blood pressure between D4Mit111 and D4Mit166 (LOD=9.8). C57BL/6-derived alleles confer increased blood pressure at Abbp2 with a recessive mode of inheritance. Abbp2 colocalizes with a previously mapped QTL named Bpq3. Human chromosome 9q31-32 is syntenic to the Abbp2 locus.
  
  Abbp3 (a female-specific QTL) mapped to mouse Chromosome 7 with peak linkage to blood pressure between D7Mit228 and D7Mit37 (LOD=5.4). C57BL/6-derived alleles confer increased blood pressure in female animals at Abbp3 with an additive mode of inheritance. Abbp3 was shown to interact with a locus at D17Mit80 (LRS=38.8).
  
  Abbp4 mapped to mouse Chromosome 11 with peak linkage to blood pressure between D11Mit212 and D11Mit124. C57BL/6-derived alleles confer increased blood pressure at Abbp4 with a recessive mode of inheritance. Candidate genes mapping near Abbp4 include Slc4a1, Car10, Cacnb1, Psa, and Igfbp4. Human chromosome 17q12-23 is syntenic to the Abbp4 locus.