Mapping Data

Experiment

• Experiment
  TEXT-Genetic Cross
• Chromosome
  5
• Reference
  J:68340 Maeda YY, et al., Two interactive genes responsible for a new inherited cataract (RCT) in the mouse. Mamm Genome. 2001 Apr;12(4):278-83
• ID
  MGI:3028178

Genes

Gene	Assay Type
mrct
D5Mit239
Crybb1	reported elsewhere
Crybb2	reported elsewhere
Crybb3	reported elsewhere
Cryba4	reported elsewhere

Notes

• Experiment
  In a RCT x (RCT x MSM/Ms)F1 backcross the a modifier of the rct phenotype was shown to be linked with with D5Mit239 (chi square 25.2). This recessively inherited locus is named mrct (modifier of Rinshoken cataract). Homozygosity for mrct accelerates the onset of cataracts in rct homozygous animals. Parental strain RCT is a cataract mutant derived from SJL/J.
  
  A cluster of beta-crystallin genes, Crybb1 (59 cM), Crybb2 (60 cM), Crybb3(60 cM), and Cryba4, map near mrct and are potential candidate genes. Crybb2, Crybb3, and Cryba4 eye RNA from inbred strains RCT, SJL/J, MSM/Ms, and MA/MyJwere synthesized and sequenced. However, no sequence variations were detected.