Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:87437 Langer JC, et al., Quantitative Trait Analysis Reveals Transforming Growth Factor-{beta}2 as a Positive Regulator of Early Hematopoietic Progenitor and Stem Cell Function. J Exp Med. 2004 Jan 5;199(1):5-14
• ID
  MGI:3029244

Genes

Gene	Assay Type
Tb2r1	visible phenotype
D4Mit158	PCR amplified length variant
D4Mit33	PCR amplified length variant
D4Mit343	PCR amplified length variant

Notes

• Experiment
  30 BXD (C57BL/6J x DBA/2J) recombinant inbred strains (RI) were analyzed for QTLs linked to the regulation of lin-Ska++-kit+ (LSK) primitive progenitor cells by TGF-beta2. The effect of 0.1 ng/ml of TGF-beta2 on LSK cell proliferation was measured. A highly suggestive QTL associated with LSK cell number, Lskcn, mapped to approximately 73 cM on mouse Chromosome 4 between D4Mit158 (67 cM) and D4Mit33 (79 cM) with LRS=13.7. Interestingly this overlaps with a highly suggestive QTL associated with LSK cell number at 79 cM (LRS=15.9 at D4Mit33 and D4Mit343) previously identified by the same authors (see J:76791). DBA/2J-derived alleles confer increased LSK cell numbers at this locus.