Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  8
• Reference
  J:72455 Burt RA, et al., Temporal expression of an H2-linked locus in host response to mouse malaria. Immunogenetics. 1999 Dec;50(5-6):278-85
• ID
  MGI:3033035

Genes

Gene	Assay Type
Char2	resistance/susceptibility
D8Mit33	PCR amplified length variant

Notes

• Experiment
  Genome scan was performed on 141 (C3H/He x C57BL/6)F2 female animals to identify QTLs associated with malaria resistance. Parental strain C3H/He is susceptible to infection by Plasmodium chabaudi adami whereas parental strain C57BL/6 is resistant. Significant linkage was detected on mouse Chromosome 17 near the H2 locus. This QTL was named Char3 and is closely linked to D17Mit21 at 18.67 cM (LOD=5.0). The C57BL/6-derived allele at Char3 confers decreased parasite load at day 11 post-infection with a dominant mode of inheritance.
  
  Previously mapped QTLs Char1 (D9Mit182) and Char2 (D8Mit33) were also detected in this study.