Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:64158 Plum L, et al., Type 2 diabetes-like hyperglycemia in a backcross model of NZO and SJL mice: characterization of a susceptibility locus on chromosome 4 and its relation with obesity. Diabetes. 2000 Sep;49(9):1590-6
• ID
  MGI:3033742

Genes

Gene	Assay Type
Nidds	resistance/susceptibility
D4Mit278	PCR amplified length variant
D4Mit232	PCR amplified length variant
Lepr	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 111 male and 96 female NZO/HlBom x (SJL/NBom x NZO/HlBom)F1 backcross animals to identify QTLs associated with susceptibility to diabetes. Parental strain NZO is obese and susceptible to diabetes whereas parental strain SJL is lean and diabetes resistant. 92 polymorphic markers were screened.
  
  A locus associated with diabetes-related traits mapped to mouse Chromosome 4 between D4Mit278 (55.2 cM) and D4Mit232 (71 cM). This locus was named Nidds. Animals heterozygous at Nidds exhibit hyperglycemia, hypoinsulinemia, and reduced body weight.