Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  1
• Reference
  J:11442 Garchon HJ, et al., Identification and mapping to chromosome 1 of a susceptibility locus for periinsulitis in non-obese diabetic mice. Nature. 1991 Sep 19;353(6341):260-2
• ID
  MGI:3033932

Genes

Gene	Assay Type
Ssial1	resistance/susceptibility
D1Nds1	PCR amplified length variant
D1Nds2	PCR amplified length variant
Bcl2	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on a population of (NOD x C57BL/6)F2 animals to identify QTLs associated with sialadenitis and periinsulitis. Parental strain NOD is susceptible to diabetes and sialitis and periinsulitis whereas parental strain C57BL/6 is resistant. Strong linkage to these phenotypes mapped near the Bcl2 locus (59.8 cM) on mouse Chromosome 1 (P<0.00025) and also showed linkage to markers D1Nds1 (66.8 cM) and D1Nds2 (59 cM). This locus was named Ssial1 (susceptibility to sialadenitis 1). Homozygosity for NOD-derived alleles at Ssial1 confers susceptibility to periinsulitis at Ssial1.