Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:76106 Leikauf GD, et al., Pathogenomic mechanisms for particulate matter induction of acute lung injury and inflammation in mice. Res Rep Health Eff Inst. 2001 Dec;105(105):5-58; discussion 59-71
• ID
  MGI:3035863

Genes

Gene	Assay Type
Aliq4	resistance/susceptibility
D6Mit183	PCR amplified length variant
Aqp1	reported elsewhere
Sftpb	reported elsewhere
Tgfa	reported elsewhere

Notes

• Experiment
  109 extreme responders from an A/J x (C67BL/6J x A/J)F1 backcross were genotyped at 77 polymorphic loci to identify QTLs associated with NiSO4-induced lung injury. Parental strain C57BL/6J is resistant to NiSO4-induced lung injury compared to parental strain A/J.
  
  A previously identified QTL, Aliq4, reached statistical significance in this study with LOD=3.0 at D6Mit183 at 26.5 cM on mouse Chromosome 6. The C57BL/6J-derived allele confers increased survival after NiSO4-induced lung injury by 12 hours compared to animals homozygous for A/J-derived alleles. Candidate genes for Aliq4 include Aqp1, Sftpb, and Tgfa.
  
  Studies with transgenic animals overexpressing human TGFA (Tg(SFTPC-TGFA)1Kor on an FVB/N background) revealed increased survival time following NiSO4-induced lung injury compared to nontransgenic animals.
  
  Suggestive linkage to NiSO4-induced lung injury mapped to 25.7 cM on mouse Chromosome 1 (LOD=2.5 near D1Mit213), 11 cM (LOD=2.3 at D12Mit185) and 22 cM (LOD=2.3 at D12Mit112) on mouse Chromosome 12, 22.5 cM on mouse Chromosome 8 (LOD=2.2 at D8Mit65), 23 cM on mouse Chromosome 9 (LOD=1.6 at D9Mit227), and 57 cM on mouse Chromosome 16 (LOD=1.6 at D16Mit152).