Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  7
• Reference
  J:3304 Watson ML, et al., Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. J Exp Med. 1992 Dec 1;176(6):1645-56
• ID
  MGI:3036012

Genes

Gene	Assay Type
Lrdm1	visible phenotype
Pou2f2	reported elsewhere
Prkcg	reported elsewhere

Notes

• Experiment
  Over 110 (MRL/MpJ-Tnfrsf6^lpr/J x CAST/Ei)F1 x MRL/MpJ-Tnfrsf6^lpr/J backcross animals were typed at 108 polymorphic loci to identify QTLs associated with nephritis. Parental strain MRL/MpJ-Tnfrsf6^lpr/J exhibits severe autoimmune nephritis compared to parental strain CAST/Ei.
  
  A locus named Lrdm1 mapped to approximately 6 cM on mouse Chromosome 7 between Pou2f2 (2 cM) and Prkcc (6 cM). MRL/MpJ-derived alleles are associated with nephritis at Lrdm1.
  
  A second locus mapped to approximately 35 cM on mouse Chromosome 12 between D12Nyu3 (27 cM) and D12Sel1 (43 cM). MRL/MpJ-derived alleles are associated with nephritis at Lrdm2.