Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:50271 Risinger FO, et al., Ethanol-induced conditioned taste aversion in BXD recombinant inbred mice. Alcohol Clin Exp Res. 1998 Sep;22(6):1234-44
• ID
  MGI:3036505

Genes

Gene	Assay Type
Taste6	visible phenotype
Cons4	visible phenotype
D11Ncvs60	PCR amplified length variant
Etohcta9	visible phenotype
D11Nds1	PCR amplified length variant

Notes

• Experiment
  841 male mice 56-125 days of ages from 20 BXD/Ty RI strains were used to map QTLs associated with ethanol-induced conditioned taste aversion behavior. Inbred strain DBA/2J exhibits increased sensitivity to ethanol compared to C57BL/6J and decreases consumption of an ethanol-paired distinctive taste (ethanol-induced taste aversion) in a dose dependent manner. Saccharin solution drinking water was used as the paired taste in this study. Etohcta9 (P<0.01 at D11Nds1; 43.8 cM) mapped to a region on Chromosome11 spanning 40 cM - 45 cM. Etohcta9 is associated with ethanol-induced taste aversion at high-dose ethanol injection following the paired taste. Taste6 mapped to a region on Chromosome 11 spanning 23 cM - 35 cM and is associated with saccharin preference. Cons4 (P<0.01 at D11Ncvs60) mapped to 74 cM and is associated with preconditioned saccharin intake.