Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:53210 Libert C, et al., Identification of a locus on distal mouse chromosome 12 that controls resistance to tumor necrosis factor-induced lethal shock. Genomics. 1999 Feb 1;55(3):284-9
• ID
  MGI:3036750

Genes

Gene	Assay Type
Tnfp	resistance/susceptibility
Serpina6	reported elsewhere
Serpina1	reported elsewhere
Serpina3kr	reported elsewhere
Serpina3k	reported elsewhere

Notes

• Experiment
  24 BXD recombinant inbred (RI) strains were analyzed for loci associated with resistance to TNF-induced lethal shock. Parental strain DBA/2J is resistant to TNF-induced lethal shock whereas parental strain C57BL/6J is susceptible.
  
  A locus named Tnfp (tumor necrosis factor protection) mapped to 54 cM on mouse Chromosome 12 with highest significant linkage to lethality at Serpina6 (LOD=6.9). Tnfp is also linked to Serpina3kr, Serpina3K (LOD=3.3), and Sperina1. Tnfp also showed association with TNF-inducedhypothermia and elevated serum IL-6. DBA/2J-derived alleles confer dominantly-inherited protection from TNF-induced lethal shock.
  
  A locus showing suggestive linkage to TNF-induced hypothermia mapped to mouse Chromosome 2 near Pmv3 (23 cM).