Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:84090 Bergeson SE, et al., Chromosomal loci influencing chronic alcohol withdrawal severity. Mamm Genome. 2003 Jul;14(7):454-63
• ID
  MGI:3037041

Genes

Gene	Assay Type
Alcw8	visible phenotype
D11Mit203	PCR amplified length variant
Gabra6	reported elsewhere
Gabrb2	reported elsewhere
Gabrg2	reported elsewhere

Notes

• Experiment
  146 (IP2 x IR1)F2 animals were genotyped at 82 polymorphic loci at a 20 cM resolution to identify QTLs associated with alcohol withdrawal severity. The IP2 (withdrawal prone) and IR1 (withdrawal resistant) inbred strains are derived from WSP (withdrawal prone) and WSR (withdrawal resistant) strains, respectively, after 20 generations of brother-sister mating.
  
  A male-specific locus mapped to mouse Chromosome 11 from 15 cM - 36 cM with peak linkage at D11Mit203 (LOD=5.7 in male animals). This locus colocalizes with Alcp3 and may represent the same QTL. Candidate genes in this region include Gabra6, Gabrb2, and Gabrg2. This locus explains 12% of the phenotypic variance.
  
  02.23.2015 Curators Note: Since Alcp3 was originally mapped in J:52086 in 1999 using a (C57BL/6J x DBA/2J)F1 x C57BL/6J backcross, which differs from the cross used here, we consider the current study a separate mapping experiment, mapping a separate QTL to D11Mit203, which we have named Alcw8.
  
  Alcw5 mapped to mouse Chromosome 1 from 28 cM - 47 cM with peak linkage at D1Mit46 (LOD=6.5). This locus explains 7% of the phenotypic variance.
  
  Alcw6 mapped to mouse Chromosome 8 from 16 cM - 43 cM with peak linkage at D8Mit4 (LOD=3.5). This locus explains 4% of the phenotypic variance.
  
  Alcw7 mapped to mouseChromosome 14 from 24 cM - 48 cM with peak linkage at D14Mit160 (LOD=4.2). This locus explains 5% of the phenotypic variance.