Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  11
• Reference
  J:25969 Gill BM, et al., Genetic linkage of thymic T-cell proliferative unresponsiveness to mouse chromosome 11 in NOD mice. A possible role for chemokine genes. Diabetes. 1995 Jun;44(6):614-9
• ID
  MGI:3037301

Genes

Gene	Assay Type
Idd4	resistance/susceptibility
Ccl3	reported elsewhere
Ccl4	reported elsewhere
Ccl2	reported elsewhere
Mpo	reported elsewhere
Xmv42	reported elsewhere
Mpmv4	reported elsewhere
D11Mit38	PCR amplified length variant
D11Nds1	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on a BXD recombinant inbred (RI) panel, a (NOD x C57BL/6)F2 intercross, and on a (NOD x C57BL/6)F1 x NOD backcross population to map QTLs associated with T-cell proliferative repsonsiveness in relation to insulin dependent diabetes mellitus. Parental strain C57BL/6 exhibits high T-cell proliferation in response to stimulation of the T cell receptor/CD3 complex whereas parental strains DBA/2 and NOD exhibits low T-cell proliferative response.
  
  In the BXD population a statistically significant locus mapped to 49 cM on mouse Chromosome 11 near Mpo (P=0.001-0.002). This region includes Ccl2, Ccl3, Ccl4, Xmv42, and Mpmv4. In the (NOD x C57BL/6)F1 x NOD backcross and the (NOD x C57BL/6)F2 intercross, statistical significance is associated with a locus near D11Mit38 at 49 cM on mouse Chromosome 11. This locus is thought to represent Idd4. Homozygosity for C57BL/6-derived alleles confers increased T-cell proliferation at this locus.