Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  17
• Reference
  J:21801 Festing MF, et al., At least four genes and sex are associated with susceptibility to urethane-induced pulmonary adenomas in mice. Genet Res. 1994 Oct;64(2):99-106
• ID
  MGI:3039002

Genes

Gene	Assay Type
Pas2	resistance/susceptibility
H2	reported elsewhere
Lta	reported elsewhere

Notes

• Experiment
  Linkage analysis was performed on 37 AXB and BXA (A= A/J, B= C57BL/6J) recombinant inbred strains to identify QTLs associated with pulmonary adenoma susceptibility. Significant association was detected at 71 cM on mouse Chromosome 6 near Kras (P<0.01) and at 23 cM on mouse Chromosome 17 near the H2 locus (P<0.01). These loci are named Pas1 and Pas2, respectively. Animals homozygous for A/J-derived alleles at Pas1 exhibit increased frequency of pulmonary adenomas. Pas1 accounted for 40% of the phenotypic variance. Animals homozygous for A/J-derived alleles at Pas2 exhibit increased frequency of pulmonary adenomas. Pas2 accounted for 18% of the phenotypic variance.
  
  A (C57BL/6JOlaHsd x A/JOlaHsd)F2 intercross population and (C57BL/6JOlaHsd x A/JOlaHsd)F1 x A/JOlaHsd and (C57BL/6JOlaHsd x A/JOlaHsd)F1 x C57BL/6JOlaHsd backcross populations were also analyzed for linkage to pulmonary adenoma susceptibility.
  
  Significant association was identified at Pas1 (71 cM) on chromosome 6 (P<0.000 at Kras), Pas2 (19 cM) on chromosome 17 (P<0.000 at Lta),
  Pas3 (15 cM) on chromosome 19 (P<0.049 at D19Mit16) and
  Pas4 (48 cM) on chromosome 9 (P<0.000 at D9Mit11).
  
  All four loci appear to exhibit an additive mode of inheritance. Variation at Kras locus accounted for 60% of the total variation in this cross while the other three loci (Pas2, Pas3, Pas4) combined account for 15% of the total variation. Pas3 alone accounts for 1.8% of the phenotypic variation while Pas4 alone accounts for 3.7% of the phenotypic variation.