Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  6
• Reference
  J:22173 Devereux TR, et al., Assignment of a locus for mouse lung tumor susceptibility to proximal chromosome 19. Mamm Genome. 1994 Dec;5(12):749-55
• ID
  MGI:3039013

Genes

Gene	Assay Type
Pas15	resistance/susceptibility
Kras	reported elsewhere
D6Int1	reported elsewhere

Notes

• Experiment
  Linkage analysis using 77 polymorphic markers was performed on a population of (A/J x C57BL/6J)F1 x C57BL/6J backcross animals to identify QTLs associated with pulmonary adenoma susceptibility. Parental strain A/J is susceptible to ENU-induced pulmonary adenomas whereas parental strain C57BL/6J is resistant.
  
  A QTL, peak LOD=4.78 was localized to a region of Chromosome 6 flanked by Kras and closely linked distal markers linked with D6Int1.
  
  12.14.2015. Curator Note: Authors have equated this QTL with Pas1. However, since Pas1 was orginally mapped in J:17778, in 1997 using an (C57BL/6J x A/J)F2 intercross where the direction of the cross varied from that of the cross used here we consider this a separate map experiment and have labeled this QTL, Pas15. This locus is 50% of the genetic variance.
  
  Significant association mapped to approximately 16 cM on mouse Chromosome 19 between D19Mit42 and D19Mit19. This locus is called Pas3 and explains 10% of the genetic variance. Candidate genes mapping near Pas3 are Tnfrsf6 (formerly Fas) and Slc3a2 (formerlyMdu1).
  
  12.14.2015. Curator Note: Pas3 was originally mapped in J:21801 using pooled results from a (C57BL/6JOlaHsd x A/JOlaHsd)F2 intercross population and (C57BL/6JOlaHsd x A/JOlaHsd)F1 x A/JOlaHsd and (C57BL/6JOlaHsd x A/JOlaHsd)F1 x C57BL/6JOlaHsd backcross populations. Because the direction of the cross used to generate the F1 female differs in this study we consider this a separate map experiment and have named the QTL Pas16.
  
  Pas15 and Pas16 appear to interact. Heterozygosity at both Pas15 and Pas16 confers increased tumor count compared to the other genotypes.