Mapping Data

Experiment

• Experiment
  TEXT-QTL-Candidate Genes
• Chromosome
  4
• Reference
  J:88800 Fehr C, et al., Potential pleiotropic effects of Mpdz on vulnerability to seizures. Genes Brain Behav. 2004 Feb;3(1):8-19
• ID
  MGI:3040350

Genes

Gene	Assay Type
Alcw2	visible phenotype
Mpdz	reported elsewhere

Notes

• Experiment
  Mpdz, a candidate gene for the alcohol withdrawal QTL Alcw2 on mouse Chromosome 4, was examined in this study. Short term selected lines were generated from a (C57BL/6J x DBA/2J)F2 intercross. Animals were selected for high alcohol withdrawal (HAW) or low alcohol withdrawal (LAW) phenotypes and bred for 4 generations. DBA/2J-derived alleles at Mpdz were enriched in the HAW population whereas C57BL/6J-derived alleles were enriched in the LAW population. This association is significant and exceeds that predicted from genetic drift.
  
  The same short term selection strategy was used to generate high pentobarbital withdrawal (HPW) and low pentobarbital withdrawal (LPW) lines. Similarly, DBA/2J-derived alleles at Mpdz were enriched in the HPW population whereasC57BL/6J-derived alleles were enriched in the LPW population. This association is significant and exceeds that predicted from genetic drift.