Mapping Data

Experiment

• Experiment
  TEXT-Congenic
• Chromosome
  4
• Reference
  J:81490 Robling AG, et al., Evidence for a skeletal mechanosensitivity gene on mouse chromosome 4. FASEB J. 2003 Feb;17(2):324-6
• ID
  MGI:3040361

Genes

Gene	Assay Type
Bmd7	visible phenotype

Notes

• Experiment
  A congenic strain containing a C3H/HeJ-derived region of mouse Chromosome 4 containing the Bmd7 QTL on a C57BL/6J genetic background was constructed. This congenic was named B6.C3H-4T. Parental strain C3H/HeJ exhibits increased femoral and vertebral bonemineral density (BMD) and decreased skeletal sensitivity to mechanical stimulation compared to parental strain C57BL/6J.
  
  The B6.C3H-4T congenic exhibits increased skeletal sensitivity to mechanical stimulation as well as increased rate of bone formation compared to C57BL/6J. This is interesting since donor strain C3H/HeJ is less sensitive to mechanical stress than C57BL/6J. This is evidence that genes exist in the C3H/HeJ background which contribute to skeletal mechanosensitivity.