Mapping Data

Experiment

• Experiment
  TEXT
• Chromosome
  10
• Reference
  J:74617 Wu T, et al., Genetic control of a mouse serum lipoprotein factor that inactivates murine leukemia viruses: evaluation of apolipoprotein f as a candidate. J Virol. 2002 Mar;76(5):2279-86
• ID
  MGI:3040954

Genes

Gene	Assay Type
Lvif	visible phenotype
D10Mit269	PCR amplified length variant
Apof	reported elsewhere

Notes

• Experiment
  99 (CAST/Ei x NSF/N)F1 x NSF/N backcross animals were typed at 58 polymorphic loci to map Lvif (leukemia virus-inactivating factor). Parental strain CAST/Ei is factor-positive whereas parental strain NSF/N is factor-negative. Lvif mapped to 70 cM on mouse Chromosome 10 near D10Mit269. Apof was identified as a tightly linked candidate gene for Lvif. However, sequence analysis of Apof did not reveal polymorphism that would lead to expression differences between LVIF-positive strain BALB/cJ and LVIF-negative strain NSF/N. The position of Lvif is syntenic to human Chromosome 12q13-14.