Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  4
• Reference
  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• ID
  MGI:3043707

Genes

Gene	Assay Type
Lwq22	visible phenotype
D4Mit1	PCR amplified length variant
D4Mit27	PCR amplified length variant
Kidq4	visible phenotype
Lwq21	visible phenotype
D4Mit64	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.
  
  On mouse Chromosome 4, QTLs for liver weight (Lvrq9, Lvrq8) and kidney weight (Kidq4) were identified. Lvrq9 maps to 32.6 cM (LOD=3.9) between D4Mit1 and D4Mit27, and Lvrq8 maps to 49.3 cM (LOD=4.0) between D4Mit27 and D4Mit64. L6-derived alleles confer recessively inherited decrease in liver weight at both Lvrq9 and Lvrq8. The confidence interval of Lvrq9 spans 15.3 cM - 42.5 cM and the confidence interval of Lvrq8 spans 42.5 cM - 58.2 cM. Kidq4 maps to 42.5 cM (LOD=5.3) between D4Mit1 and D4Mit27 with L6-derived alleles conferring dominantly inherited decrease in kidney weight. The confidence interval of Kidq4 spans 19.5 cM - 52.1 cM.