Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  12
• Reference
  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• ID
  MGI:3043713

Genes

Gene	Assay Type
Lwq23	visible phenotype
D12Mit5	PCR amplified length variant
D12Mit8	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.
  
  On mouse Chromosome 12, liver weight QTL Lvrq10 mapped to 53.2 cM (LOD=3.5) between D12Mit5 and D12Mit8 with L6-derived alleles conferring dominantly inherited decrease in liver weight.