Mapping Data

Experiment

• Experiment
  TEXT-QTL
• Chromosome
  16
• Reference
  J:87793 Rocha JL, et al., A large-sample QTL study in mice: II. Body composition. Mamm Genome. 2004 Mar;15(2):100-13
• ID
  MGI:3043717

Genes

Gene	Assay Type
Splq8	visible phenotype
D16Mit55	PCR amplified length variant
D16Mit57	PCR amplified length variant

Notes

• Experiment
  Linkage analysis was performed on 552 10-week old male animals from a (M16i x L6)F2 intercross to identify QTLs associated with measurements of growth such as organ weight, growth rate, and adiposity. 63 polymorphic markers spanning the 19 autosomes wereused in the genome scan. Parental strain M16i is a long term selection line for rapid 3- and 6- week weight gain whereas parental strain L6 is a long term selection line for low 6-week body weight. A total of 50 significant QTLs (LOD>3.3) were mapped over 15 chromosomes. More than 25% of loci mapped to mouse Chromosome 2.
  
  On mouse Chromosome 16, spleen weight QTL Splq8 mapped to 3.4 cM (LOD=3.9) between D16Mit55 and D16Mit57 with L6-derived alleles conferring dominantly inherited decrease in spleen weight.